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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1979 1
1980 1
1981 1
1982 1
1983 2
1984 5
1985 8
1986 8
1987 14
1988 22
1989 23
1990 37
1991 53
1992 56
1993 89
1994 76
1995 92
1996 102
1997 111
1998 133
1999 136
2000 138
2001 140
2002 142
2003 123
2004 152
2005 134
2006 147
2007 168
2008 157
2009 166
2010 175
2011 197
2012 201
2013 195
2014 217
2015 186
2016 191
2017 216
2018 188
2019 207
2020 188
2021 208
2022 187
2023 153
2024 64

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4,830 results

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Page 1
RNA Splicing by the Spliceosome.
Wilkinson ME, Charenton C, Nagai K. Wilkinson ME, et al. Annu Rev Biochem. 2020 Jun 20;89:359-388. doi: 10.1146/annurev-biochem-091719-064225. Epub 2019 Dec 3. Annu Rev Biochem. 2020. PMID: 31794245 Review.
The spliceosome removes introns from messenger RNA precursors (pre-mRNA). Decades of biochemistry and genetics combined with recent structural studies of the spliceosome have produced a detailed view of the mechanism of splicing. ...Removal of t …
The spliceosome removes introns from messenger RNA precursors (pre-mRNA). Decades of biochemistry and genetics c …
Alternative Splicing and Isoforms: From Mechanisms to Diseases.
Liu Q, Fang L, Wu C. Liu Q, et al. Genes (Basel). 2022 Feb 24;13(3):401. doi: 10.3390/genes13030401. Genes (Basel). 2022. PMID: 35327956 Free PMC article. Review.
Alternative splicing of pre-mRNA is a key mechanism for increasing the complexity of proteins in humans, causing a diversity of expression of transcriptomes and proteomes in a tissue-specific manner. ...Further understanding of alternative splicing reg …
Alternative splicing of pre-mRNA is a key mechanism for increasing the complexity of proteins in humans, causing a dive …
Targeting the splicing factor NONO inhibits GBM progression through GPX1 intron retention.
Wang X, Han M, Wang S, Sun Y, Zhao W, Xue Z, Liang X, Huang B, Li G, Chen A, Li X, Wang J. Wang X, et al. Theranostics. 2022 Jul 11;12(12):5451-5469. doi: 10.7150/thno.72248. eCollection 2022. Theranostics. 2022. PMID: 35910786 Free PMC article.
Background: Splicing factors are essential for nascent pre-mRNA processing and critical in cancer progression, suggesting that proteins with splicing functions represent potential molecular targets for cancer therapy. ...RIP-PCR and RNA p …
Background: Splicing factors are essential for nascent pre-mRNA processing and critical in cancer progression, s …
Capture RIC-seq reveals positional rules of PTBP1-associated RNA loops in splicing regulation.
Ye R, Hu N, Cao C, Su R, Xu S, Yang C, Zhou X, Xue Y. Ye R, et al. Mol Cell. 2023 Apr 20;83(8):1311-1327.e7. doi: 10.1016/j.molcel.2023.03.001. Epub 2023 Mar 22. Mol Cell. 2023. PMID: 36958328 Free article.
RNA-binding proteins (RBPs) bind at different positions of the pre-mRNA molecules to promote or reduce the usage of a particular exon. ...These "positional rules" can faithfully predict PTBP1-regulated splicing outcomes. We further demonstrate that can …
RNA-binding proteins (RBPs) bind at different positions of the pre-mRNA molecules to promote or reduce the usage of a p …
Structure of the activated human minor spliceosome.
Bai R, Wan R, Wang L, Xu K, Zhang Q, Lei J, Shi Y. Bai R, et al. Science. 2021 Mar 19;371(6535):eabg0879. doi: 10.1126/science.abg0879. Epub 2021 Jan 28. Science. 2021. PMID: 33509932
The minor spliceosome mediates splicing of the rare but essential U12-type precursor messenger RNA. ...
The minor spliceosome mediates splicing of the rare but essential U12-type precursor messenger RNA. ...
Light-regulated pre-mRNA splicing in plants.
Kathare PK, Huq E. Kathare PK, et al. Curr Opin Plant Biol. 2021 Oct;63:102037. doi: 10.1016/j.pbi.2021.102037. Epub 2021 Apr 3. Curr Opin Plant Biol. 2021. PMID: 33823333 Free PMC article. Review.
Moreover, several phy-interacting splicing factors/regulators from different species have been identified using forward genetics and protein-protein interaction studies, which modulate the light-regulated pre-mRNA splicing. In this article, we s …
Moreover, several phy-interacting splicing factors/regulators from different species have been identified using forward geneti …
The pre-mRNA splicing factor RDM16 regulates root stem cell maintenance in Arabidopsis.
Lv B, Hu K, Tian T, Wei K, Zhang F, Jia Y, Tian H, Ding Z. Lv B, et al. J Integr Plant Biol. 2021 Apr;63(4):662-678. doi: 10.1111/jipb.13006. Epub 2020 Sep 16. J Integr Plant Biol. 2021. PMID: 32790237
Pre-mRNA (messenger RNA) splicing participates in the regulation of numerous biological processes in plants. ...However, no study has revealed a role for splicing in maintaining the root stem cell niche. Here, a screen for defects in root growth …
Pre-mRNA (messenger RNA) splicing participates in the regulation of numerous biological processes in plants. ... …
AI-assisted proofreading of RNA splicing.
Guerra-Moreno Á, Valcárcel J. Guerra-Moreno Á, et al. Genes Dev. 2023 Dec 26;37(21-24):945-947. doi: 10.1101/gad.351373.123. Genes Dev. 2023. PMID: 38092520 Free PMC article. Review.
RNA helicases orchestrate proofreading mechanisms that facilitate accurate intron removal from pre-mRNAs. How these activities are recruited to spliceosome/pre-mRNA complexes remains poorly understood. In this issue of Genes & Development, Zhang an …
RNA helicases orchestrate proofreading mechanisms that facilitate accurate intron removal from pre-mRNAs. How these activities …
The Rice Serine/Arginine Splicing Factor RS33 Regulates Pre-mRNA Splicing during Abiotic Stress Responses.
Butt H, Bazin J, Prasad KVSK, Awad N, Crespi M, Reddy ASN, Mahfouz MM. Butt H, et al. Cells. 2022 May 30;11(11):1796. doi: 10.3390/cells11111796. Cells. 2022. PMID: 35681491 Free PMC article.
Abiotic stresses profoundly affect plant growth and development and limit crop productivity. Pre-mRNA splicing is a major form of gene regulation that helps plants cope with various stresses. Serine/arginine (SR)-rich splicing factors play a key …
Abiotic stresses profoundly affect plant growth and development and limit crop productivity. Pre-mRNA splicing is a maj …
SWAP1-SFPS-RRC1 splicing factor complex modulates pre-mRNA splicing to promote photomorphogenesis in Arabidopsis.
Kathare PK, Xin R, Ganesan AS, June VM, Reddy ASN, Huq E. Kathare PK, et al. Proc Natl Acad Sci U S A. 2022 Nov;119(44):e2214565119. doi: 10.1073/pnas.2214565119. Epub 2022 Oct 25. Proc Natl Acad Sci U S A. 2022. PMID: 36282917 Free PMC article.
Here, we report the identification and functional characterization of an RNA-binding splicing factor, SWAP1 (SUPPRESSOR-OF-WHITE-APRICOT/SURP RNA-BINDING DOMAIN-CONTAINING PROTEIN1). ...Our study uncovered the function of a splicing factor …
Here, we report the identification and functional characterization of an RNA-binding splicing factor, SWAP1 (SUPPRESSOR …
4,830 results